Great Skin Coupons and

Great Skin Coupons and Great Skin Coupon Codes Welcome Guest, Customize Quicktoclick.com Coupons Shopping Gift Certificates Merchant Login Apparel Baby Beauty & Fragrance Books Computers Electronics Flowers & Gifts Gourmet Health & Personal Care Home & Garden Jewelry Kitchen Music & DVD Office Pets Sports Tools Toys & Games Travel Join our Mailing List Coupon Forums Search For... Find Merchants by Name # A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Great Skin Coupons and Great Skin Coupon Codes - Always updated daily - Always free to use Great Skin www.greatskin.com Great Skin sells skincare products and offers skincare research information, including Obagi, M.D. Forte, Dermalogica, DCL, Zirh, Bioelements, anti-aging research. Rating: Not Yet Rated Votes: 0, Vote Here Coupons Product Deals Great Skin Coupon Save 5% when you order 3 items or more! Click link above to activate coupon code. Expires Ongoing Send to a Friend , Discuss Tips for Using Great Skin Coupons Some Great Skin coupon codes may only be used once per person. We try to indicate this when possible. Free Shipping coupons are often limited to ground shipping within the continental United States. We try to indicate this when possible. Great Skin coupons with expiration dates of "Unknown" mean no expiration date has been supplied to us from Great Skin and the coupon code may have expired. Great Skin coupons with an expiration date of "ongoing," do not have a expiration date Great Skin may expire their coupons before the advertised expiration date on our website. Always verify that your Great Skin coupon code has been accepted and the discount is reflected in your purchase price before submitting your purchase. Some online coupons are case-sensitive while others are not. Be sure to enter the Great Skin coupon code exactly as we have them displayed on our website. We recommend you cut and paste the coupon code in the field provided. Quick Pick - 1/26/2006 Cooking.com Save 15% on Any Single Item! Discount will apply to the item with the highest price. Excludes All-Clad, Breville, Capresso, Chef'sChoice, Emerilware, Global, Henckels, Kershaw, KitchenAid Stand Mixers, Krups, Kuhn Rikon, Le Creuset, Musso, Saeco, Screwpull, Seattle's Best Coffee, Starbucks, Torrefazione, Viking, Wusthof, clearance items, and gift certificates. Use coupon code - C98248 Expires 1/26/2006 Ads by Google Great Skin Customers also Browse Biotherm (0) coupons Not Rated DERMAdoctor (2) coupons H20 Plus (0) coupons Jaqua (0) coupons L'occitane (1) coupon Murad (0) coupons Proactiv Solution (0) coupons Rodan + Fields (0) coupons Not Rated Skin Store (1) coupon SpaLook (3) coupons The Body Shop (2) coupons Yves Rocher (4) coupons Rate Great Skin Please take a moment and rate the Greatskin.com shopping experience. All Great Skin feedback is derived solely from our customers. 5 Stars ( Best ) 4 Stars 3 Stars 2 Stars 1 Star Advertisements Online Dating Zeroweb.org Save Money Advice Contact Us | Privacy Policy | Terms Of Use | Forums | Links © 2003-2005 Quicktoclick.com™ - All Rights Reserved

Microdermabrasion System Other products

Amazon.com: Conair Moisturizing Mist Microdermabrasion System: Health & Personal Care Your Store Health & Personal Care See All 32 Product Categories   Your Account | Cart | Wish List | Help | Browse Brands & Products | Top Sellers | Health Care | Personal Care | Shaving & Hair Removal | Nutrition & Fitness | Baby & Child Care | Sales & Special Offers Search Amazon.com Health & Personal Care Web Search Join Amazon Prime and ship Two-Day for free and Overnight for $3.99. Already a member? Sign in . RELATED ITEMS Conair TS7N Jumbo Rollers Instant Heat Travel Hairsetter Price: $16.99 Conair CS19JCS Instant Heat Ceramic Hair Straightener Price: $19.88 ITEM INFORMATION Explore this item buying info label information accessories customer reviews shipping information rate this item See more by this brand Conair Customers also bought these other items... Share your thoughts write a review write a So You'd Like to... guide tell a friend about this item RATE THIS ITEM I dislike it I love it! 1 2 3 4 5 Edit your ratings Visit the Kitchen & Housewares Store Divatex 260-Thread-Count 100% Cotton Stripe Full/Queen Duvet with Bonus Standard Shams, White Amazon.com Price: $24.99 Availability: Usually ships in 24 hours Quantity: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Sign in to turn on 1-Click ordering. A9.com users save 1.57% on Amazon. Learn how . Target Price: $24.99 Availability: Usually ships in 24 hours Closeouts Price: $27.99 Availability: Usually ships in 1-2 business days Brand Variety Price: $36.99 Availability: Usually ships in 1-2 business days 4 new, used & refurbished from $24.99 Conair Moisturizing Mist Microdermabrasion System Other products by Conair See more pictures and other information List Price: $36.99 Price: $24.99 & eligible for FREE Super Saver Shipping on orders over $25. See details . You Save: $12.00 (32%) Availability: Usually ships within 24 hours Features: On/Off Switch Warm Steam Facial Sauna Cone to Concentrate Mist on Face Auto Shutoff and Timer Microdermabrasion tool with 2 attachments Amazon.com Sales Rank: #367 in Health & Personal Care(See Top Sellers in Health & Personal Care ) Yesterday: #475 in Health & Personal Care Shipping: Currently, item can be shipped only within the U.S. Shipping weight: 2.35 pounds. ASIN: B00005A9WP Dimensions: 0.00 inches x 0.00 inches x 0.00 inches Date first available at Amazon: March 21, 2001 Average Customer Review: Based on 6 reviews. Write a review . Customers who bought this itemalso bought these items: Panasonic EH2511A Pore Cleanser with Micro-fine Mist Panasonic Conair 5-in-1 Style Set (Color May Vary) Conair Homedics Facial Spa Ultra Cleansing and Microdermabrasion System - FAC-200 HoMedics Homedics Facial Spa - FAC-100 HoMedics Explore Similar Items : 16 in Kitchen & Housewares , 1 in Apparel , and 3 in Electronics Label Information Amazon.com Review This unit can be used to steam open pores for cleansing skin and to steam open clogged nasal and sinus passages. The versatility comes from two translucent, blue, plastic cones. The large cone is 6-3/4 inches wide and has a flared, open side to accommodate the face, chin, and neck for cleansing. The small cone is 3-1/2 inches wide, so steam is directed into the nose where it can be breathed in during allergy and cold season. Operating the steamer is simple: using the included measuring tube, pour tap water into the power base's reservoir; twist on and lock into place either of the tubes; switch on the unit with the on/off button; and wait about three minutes for the water to heat. For controlled cleansing sessions there's a timer than can be set from 3 to 15 minutes. And for safety the unit automatically shuts off after 45 minutes. --Fred Brack Product Description A combination of thorough pore-cleaning steam mist from a Facial Sauna followed by a gentle exfoliation using a rotating Microdermabrasion tool. It can transform skin. Give yourself a facial in the comfort of your own home with this Conair facial spa. The wide facial cone uses gentle steam to open clogged pores and rejuvenate skin. The narrow sinus cone was designed to help clear nasal and sinus passages to aid in respiratory therapy. Also features a timer, automatic shutoff and a water cylinder for easy and accurate filling. Plastic. Imported. 9Hx7.5Wx8.25D" Spotlight Reviews (What's this?) Write an online review and share your thoughts with other customers. Search Customer Reviews 66 of 68 people found the following review helpful: I like this thing , January 12, 2005 Reviewer: Mikhail (Cleveland, OH USA)- See all my reviews I decided to become a metrosexual at the age of 41 and bought this neat unit to celebrate. I wasn't expecting much, but it does its job. It's simple to use and I can see the difference in my skin after using it only a short time. I'm especially fond of the microdermabrasian tool. I use it with some inexpensive scrub and my face never felt smoother. The only possible down side is that it takes a while for the steam to get hot enough to feel like it's making any difference. The instructions say that it should take about three minutes, but I allow twice that and everything is fine. I'm in no hurry. :) Was this review helpful to you? ( Report this ) All Customer Reviews Average Customer Review: Write an online review and share your thoughts with other customers. 6 of 6 people found the following review helpful: Conair: The Complete Facial Spa , November 27, 2005 Reviewer: T. Mccartney - See all my reviews Overall, I like this product. It is rather relaxing to sit and pamper yourself. The unit makes short of a hissing noise as the water boils, but it's not too loud. Make sure to keep an eye on the water level. It shouldn't all evaporate if you only do this for, say, 10 minutes, however longer times require water to be added and if you don't add the water in time sort of a "burn" smell results. Add the water before putting the blue top on - otherwise it sort of pours out here and there. I don't like to use the timer because the beep noise is really loud and annoying. I wish the face cone was longer as well (as someone else noted) - while the steam doesn't hurt my nose - it does sting my forhead if I tilt my head to steam that area. I also do not like how your hairline and sides of your face to not get steamed unless you turn your head, which is uncomfortable. I recommend putting the unit on a few phonebooks (if you don't mind possibly spilling water on them) to ease have to bend your back and/or neck so far down. Keep napkins nearby to move the unit - so as to not burn your hands if water spills. Don't put lotion on your face or else it will end up smeared all over the blue part (eye area might be ok). The unit I purchased did not come with a face scrubber, so I have no comment on that. If you take the blue part OFF the unit (once it cools off and you remove the water), it will better fit in the original box for storage!! Was this review helpful to you? ( Report this ) 7 of 7 people found the following review helpful: so far very happy with this product , November 22, 2005 Reviewer: Zuzana Vass "Zuzana" (San Diego,CA)- See all my reviews I just received this product yesterday, and used it the same evening. It took approximately 3-5 minutes for water to heat up. Meanwhile I washed my face and put some cream on my eye area (btw, that was a good tip from manual, as you protect your sensitive skin around eyes). Steam was very good and strong, but I would probably be more happier if the facial cone was a bit longer, so my face is not so very close to the steam coming right out of the machine. I think using a towel over your head will be very helpful if you want to steam your face for more than 10 minutes. Just to add more effect to your steam facial treatment :) I set the timer on 10 minutes first time and it did work. I have been using my facial brush to exfoliate my face in the shower, but I like this facial brush that comes with this product. Brush is very soft and work pretty well. I thing this brush is more gentle but yet more effective than just using my old brush. It is not so harsh on your face. Use a generous amount of cream or moisturizer after using brush to exfoliate your face. Also, my personal recommendation - I would probably not use brush to exfoliate your facial skin more often than once in a week or two. Facial skin is very thin in general.. you don`t want to take it completely off :) Using mask right after steaming is very good idea too. Yes, I have been using boiling water in pot so far, but I find this product to be very convenient way of doing steam facial. And one more tip, if you still miss steaming your face over a boiling pot with herbs (sage is excellent thing) use this herbal tea instead of using mask.. Simply damp the towel and put it on your face for couple of minutes after steaming. So like I`ve said - product works very well and I am so far very happy with it. Enjoy! Was this review helpful to you? ( Report this ) 5 of 5 people found the following review helpful: Exactly what i was looking for , November 8, 2005 Reviewer: Bridgette Ards (Austin, TX.)- See all my reviews Yes, it takes longer than a few minutes to warm up, but once it is steaming full strength it works miracles. I just turn it on while washing my face with the exfoliator brush before hand. The steamer opens your pores, and helps pull out impurities. I put a mask on directly afterwards to complete my facial. It also primes your face to get better results from your anti-aging and moisturizing products. You can also add a couple of drops of your favorite essential oils to help you relax or aid in the clearing of problem skin. Was this review helpful to you? ( Report this ) 5 of 10 people found the following review helpful: comme la, comme sa , September 12, 2005 Reviewer: BM_NINADA "Music Crazy" (Jersey City, NJ)- See all my reviews Ok - for those who want to do a general facial sauna. The gadgets can be safely thrown away, the nose-apapter is useless. Takes some time to start up and in my case the timer does not work. Don't want to be harsh, since it might very well be only for me but the bottom-line is a crude cheap product which I WILL ADVICE to purchase if you're looking for a simple model doing just that steaming to your face and you're ready to wait for 10 min. while the stuff heats up. Was this review helpful to you? ( Report this ) See all 6 customer reviews... Suggestion Box Your comments can help make our site better for everyone. If you've found something incorrect, broken, or frustrating on this page, let us know so that we can improve it. Please note that we are unable to respond directly to suggestions made via this form. If you need help with an order, please contact Customer Service . Please mark as many of the following boxes that apply: Product information is missing important details. Product information is incorrect. The page contains typographical errors. The page takes too long to load. The page has a software bug in it. Content violates Amazon.com's policy on offensive language . Product offered violates Amazon.com's policy on items that can be listed for sale. Comments or Examples: Examples: Missing information such as dimensions and model number, typos, inaccuracies, etc. Health & Personal Care Disclaimer: Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. When you receive an item, carefully read all labels, warnings, and directions before use. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com Shipping Information Amazon.com Returns & Exchanges Contact Amazon.com Amazon.com & Your Privacy Where's My Stuff? • Track your recent orders . • View or change your orders in Your Account . Shipping & Returns • See our shipping rates & policies . • Return an item (here's our Returns Policy ). Need Help? • Forgot your password? Click here . • Redeem or buy a gift certificate. • Visit our Help department . Search Health & Personal Care All Products for Turn your past purchases into $$$ Learn more about selling at Amazon.com today! 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Gorgeous Skin in 30

Gorgeous Skin in 30 Days :: Emporium Books: Australian Bookstore -- Shipping & Returns Privacy Notice Conditions of Use Contact Us FAQ Log In My Account Cart Quick Search Advanced Search Recommendations Home Other Categories -> Health & Beauty Shopping Cart 0 items Australian based. All prices are in Australian dollars All prices are GST inclusive. Easy payment with: credit card, AMEX, cheque, money order or BPAY. Flat delivery fee: no per-item charge. FREE delivery in Australia for orders over $50! Everyday discount of 20% on hundreds of thousands of titles. Up to 80% discount on selected titles. Australian Booksellers Association member Gorgeous Skin in 30 Days $29.95 $23.96 Save $5.45 (20%) Click to enlarge Click to enlarge Author: Erica Angyal Publisher/Studio: Lothian Books Format/Zone: Paperback ISBN/APN: 0734408331 Edition: 1 Pub. Date: 2005 Weight: 601 Ships Within: 7 days The newest skin care and anti-ageing tools are the fork and the spoon! Erica Angyal explains how her detox programme and great nutrition can lead to radiant skin in just 30 days. This easy-to-read manual offers everything you need to know to achieve healthy skin and prevent premature ageing. It contains a special section for brides and those wanting flawless skin for special occasions. About the author Erica Angyal is a health practitioner, nutritionist and consultant. Born in Australia, she graduated from the Sydney University of Technology with a Bachelor of Health Science. She also has a Diploma of Nutrition and is a member of the Australian Traditional Medicine Society. She is currently based in Tokyo where she works as a nutritional consultant, as a health columnist for lifestyle magazines and presents regular seminars on preventative health and nutrition. This product was added to our catalog on Sunday 11 September, 2005. Friday 27 January, 2006 Powered by osCommerce

After Shave at Discount

Aftershaves products at MSN Shopping MSN Home My MSN Hotmail Shopping Money People & Chat Sign In Web search: Shopping Save this page Feedback Site map Help Home | Beauty | Books | Clothing | Computers | Deals | Electronics | Flowers | Home & Garden | Jewelry | Movies | Music | More ... Search Shopping Home > Beauty & Fragrance > Skin Care > Facial Care Aftershaves Advertisement Featured Stores See all stores Advertisement 1,955 items found Narrow your selection: Brand Coty Ralph Lauren Calvin Klein Dana Hugo Davidoff Adidas Carolina Herrera More... Seller FragranceNet.com Windaz.com FragranceSupplier.com PerfumeCountry.com Perfume Emporium FragranceWholeSaler www.Perfume.com NORDSTROM.com More... Price range $0 - $10 $10 - $20 $20 - $30 $30 - $40 $40 - $50 $50 - $65 $65 - $108 $ to $ Show sale items only Show free shipping only Calculated in 0.124 seconds Previous Page 1 2 3 4 5 6 7 8 9 10 of 131 Next View: List Grid Text checked items Sort by Most popular Highest user rating Lowest price Highest price Name A-Z Name Z-A JORDAN by Michael Jordan - AFTERSHAVE BALM 4 oz for Men by Jordan $22.00 Sale $10.99 JORDAN fragrances for men or women by Michael Jordan were ... More launched in 2000. This designer fragrance is a flowery blend of flowery aromas. JORDAN colognes for men by Michael Jordan fragrances are recommended for daytime wear.All Michael Jordan Perfumes, Colognes and other products we sell are name brand originals, produced and bottled by the original manufacturers. These are the exact fragrances you will find at your local department store. We never sell knock offs, spoofs or fakes. At www.Perfume.com | Details Up to 70% off Discount Fragrances Rate it HALSTON Z-14 by Halston - AFTERSHAVE LOTION 4.2 oz for Men by Halston $32.50 Sale $18.49 HALSTON Z-14 fragrances for men or women by Halston were ... More launched in 1976. This designer fragrance is a flowery blend of flowery aromas. HALSTON Z-14 colognes for men by Halston fragrances are recommended for casual wear.All Halston Perfumes, Colognes and other products we sell are name brand originals, produced and bottled by the original manufacturers. These are the exact fragrances you will find at your local department store. We never sell knock offs, spoofs or fakes. At www.Perfume.com | Details Up to 70% off Discount Fragrances Rate it Bay Rum Aftershave $11.75 The Bay Rum Aftershave is Temporarily Back OrderedThis is ... More the real thingFresh bay leaves infused into Jamaican Rum. Fresh and spicy, this makes an excellent aftershave, toner, or even underarm body scent. Traditionally a men's fragrance, Bay Rum is finding an audience with females as well. It's pure, natural and simply wonderful.4 fluid ouncesCruelty-free What to ExpectAs Pure as it GetsWhat so many companies have recreated synthetically, we offer in its purest state. Fresh and spicy, the scent lingers for quite some time after application. To protect the integrity of the ingredients, it comes in an amber bottle with a convenient spray top. There is nothing like the smell of Bay Rum on the man of your dreams. This is the scent of days gone by ...very masculine. Ingredients: Jamaican Rum, Bay leaves, Cloves, Orange peel, Essential oils of Lavender, Rosemary and Sandalwood. 4 oz. At 1 store | Details Rate it UOMO MOSCHINO by Moschino - AFTERSHAVE 4.2 oz for Men $45.00 Sale $25.89 UOMO MOSCHINO fragrances for men or women by Moschino were ... More launched in 1997. This designer fragrance is a flowery blend of flowery aromas. UOMO MOSCHINO colognes for men by Moschino fragrances are recommended for daytime wear.All Moschino Perfumes, Colognes and other products we sell are name brand originals, produced and bottled by the original manufacturers. These are the exact fragrances you will find at your local department store. We never sell knock offs, spoofs or fakes. At www.Perfume.com | Details Up to 70% off Discount Fragrances Rate it POLO by Ralph Lauren - AFTERSHAVE 1.5 oz for Men by Polo $32.49 Launched by the design house of Ralph Lauren in 1978, POLO ... More is classified as a sharp, woody, arid fragrance. This masculine scent possesses a blend of leather, wood, tobacco, basil and oakmoss. It is recommended for daytime wear. At www.Perfume.com | Details Up to 70% off Discount Fragrances Rate it ROYAL COPENHAGEN SPORT by Royal Copenhagen - AFTERSHAVE 2 oz for Men by Royal Copenhagen Perfumes and Colognes $25.00 Sale $14.89 This energetic scent is the most popular with up-beat ... More active males. This fresh, citrus scent has notes of a novel form of frankincense, vetiver, sandalwood, lemon, orange flower, jasmine, olibanum, warm mosses, and amber. This cologne is great for professional wear, but can also be worn casually. At www.Perfume.com | Details Up to 70% off Discount Fragrances Rate it HELMUT LANG by Helmut Lang - AFTERSHAVE 3.4 oz for Men by Helmut Lang $30.00 Sale $23.89 Helmut Lang is a sexy sophisticated scent by Helmut Lang, ... More introduced in 2001. This is an elegant refined scent which possesses a blend of sweet spice and oriental woods. Recommended for an evening out that you will never forget. At www.Perfume.com | Details Up to 70% off Discount Fragrances Rate it Adidas Moves by Coty - AFTERSHAVE 1.7 oz for Men by Adidas $17.50 Sale $9.95 Launched in 1999, Adidas Moves by the design house of ... More Adidas received a prestigious FiFi award in 2000. This refreshing scent is sweet and spicy. The top notes are Green Apple, Tomato Leaf, Parsley, Black Pepper, Anise, Spearmint, Peppermint, Pineapple, Mandarine. The middle notes: Ginger, Ginger Ale Accord, Cedarwood, Lavender, Jasmine, Juniper, Geranium, Musk. The base notes are Sandalwood, Thyme, Oakmoss, Muguet At www.Perfume.com | Details Up to 70% off Discount Fragrances Rate it POLO SPORT Aftershave - by RALPH LAUREN 4.2 Oz for Men by Ralph Lauren $33.75 POLO SPORT Aftershave, POLO SPORT by RALPH LAUREN ... More AFTERSHAVE 4.2 Oz contains a blend of fresh, warm, sporty florals. POLO SPORT Aftershave is Classified as a Masculine Fragrance.POLO SPORT After Shave at Discount At 1 store | Details Rate it ESCAPE Cologne by Calvin Klein AFTERSHAVE BALM 3.4 oz - Mens Cologne by Calvin Klein $14.99 ESCAPE Cologne comes in AFTERSHAVE BALM 3.4 oz. EXTRA 10% ... More Off with coupon code: PG10. Launched by the design house of Calvin Klein in 1993, ESCAPE COLOGNE is classified as a refreshing, spicy, lavender, amber fragrance. This masculine scent possesses a blend of mandarin, apple, plum, peach, rose and sandalwood. It is recommended for office wear. At 1 store | Details Rate it POLO BLUE Cologne by Ralph Lauren AFTERSHAVE GEL 4.2 oz - Mens Cologne by Ralph Lauren $24.99 POLO BLUE Cologne comes in AFTERSHAVE GEL 4.2 oz. EXTRA 10% ... More Off with coupon code: PG10. Launched by the design house of Ralph Lauren in 2002 POLO BLUE Cologne is a scent of an exquisite fragrance. At 1 store | Details Rate it ENGLISH LEATHER Cologne by Dana AFTERSHAVE 8.0 oz - Mens Cologne by Dana $13.99 ENGLISH LEATHER Cologne comes in AFTERSHAVE 8.0 oz. EXTRA ... More 10% Off with coupon code: PG10. Launched by the design house of Dana in 1949, ENGLISH LEATHER COLOGNE is classified as a sharp, woody, arid fragrance. This masculine scent possesses a blend of citrus, woods, moss and leather. It is recommended for casual wear. At 1 store | Details Rate it OSCAR POUR LUI Cologne by Oscar de la Renta AFTERSHAVE 8.0 oz. - Mens Cologne by Oscar de la Renta $41.99 OSCAR POUR LUI Cologne comes in AFTERSHAVE 8.0 oz.. EXTRA ... More 10% Off with coupon code: PG10. Launched by the design house of Oscar de la Renta in 1977 OSCAR POUR LUI Cologne is a scent of an exquisite sharp, oriental, woody fragrance. At 1 store | Details Rate it OPIUM Cologne by Yves Saint Laurent AFTERSHAVE 3.4 oz - Mens Cologne by Yves Saint Laurent $28.99 OPIUM Cologne comes in AFTERSHAVE 3.4 oz. EXTRA 10% Off ... More with coupon code: PG10. Launched by the design house of Yves Saint Laurent in 1995 OPIUM Cologne is a scent of an exquisite sharp, oriental, woody fragrance. At 1 store | Details Rate it Adidas ADIDAS MOVES GIFTSET EDT SPRAY 1.7 OZ & AFTERSHAVE BALM 1 OZ by Adidas $19.89 EDT SPRAY 1.7 OZ & AFTERSHAVE BALM 1 OZ for MEN jasmine, ... More black pepper, and clove, spicy and masculine. 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BOTOX TO TREAT FROWN

FDA APPROVES BOTOX TO TREAT FROWN LINES FDA Talk Papers are prepared by the Press Office to guide FDA personnel in responding with consistency and accuracy to questions from the public on subjects of current interest. Talk Papers are subject to change as more information becomes available. T02-20 Media Inquiries: 301-827-6242 April 15, 2002 Consumer Inquiries: 888-INFO-FDA FDA APPROVES BOTOX TO TREAT FROWN LINES FDA today announced the approval of Botulinum Toxin Type A (Botox Cosmetic) to temporarily improve the appearance of moderate to severe frown lines between the eyebrows (glabellar lines), a medical condition that is not serious. The product's manufacturer, Allergan, Inc., Irvine, California, is now allowed to market Botulinum Toxin Type A for this new indication. Botulinum Toxin Type A is a protein produced by the bacterium Clostridium botulinum . When used in medical settings as an injectable form of sterile, purified botulinum toxin, small doses of the toxin are injected into the affected muscles and block the release of the chemical acetylcholine that would otherwise signal the muscle to contract. The toxin thus paralyzes or weakens the injected muscle. Botox was first approved in December 1989, to treat two eye muscle disorders (blepharospasm and strabismus) and in December 2000 to treat cervical dystonia, a neurological movement disorder causing severe neck and shoulder contractions. In placebo-controlled, multicenter, randomized clinical trials involving a total of 405 patients with moderate to severe glabellar lines who were injected with Botox Cosmetic, data from both the investigators' and the patients' ratings of the improvement of the frown lines were evaluated. After 30 days, the great majority of investigators and patients rated frown lines as improved or nonexistent. Very few patients in the placebo group saw similar improvement. In these studies, the severity of the glabellar lines was reduced somewhat for up to 120 days for those patients who received Botox Cosmetic. Most of the patients in the study were female, and the majority was under 50 years old. It is recommended that Botox Cosmetic be injected no more frequently than once every three months, and the lowest effective dose should be used. The most common adverse events following injection were headache, respiratory infection, flu syndrome, blepharoptosis (droopy eyelids) and nausea. Less frequent adverse reactions (less than 3% of patients) included pain in the face, redness at the injection site and muscle weakness. These reactions were generally temporary, but could last several months. Because Botox Cosmetic is a prescription drug, it must be used carefully under medical supervision. ### FDA News Page |   FDA Home Page Office of Public Affairs Web page uploaded by tg 2002-APR-15.