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Pulmonary arterial hypertension in patients with sleep apnoea syndrome -- Bady et al. 55 (11): 934 -- Thorax HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Cited by other online articles Google Scholar Articles by Bady, E Articles by Laaban, J-P Articles citing this Article PubMed PubMed Citation Articles by Bady, E Articles by Laaban, J-P Related Collections Sleep Apnea Thorax 2000; 55 : 934-939( November ) Pulmonary arterial hypertension in patients with sleep apnoeasyndrome E Bady, A Achkar, S Pascal, E Orvoen-Frija, J-P Laaban Department ofPneumology, Hotel-Dieu, 75181 Paris Cedex 04, France Correspondence to: Professor J-PLaaban j-pierre.laaban{at}htd.ap-hop-paris.fr Received 19 April 1999 ; Returned to authors 9 July 1999 ; Revised version received 24 March 2000 ; Accepted for publication 25July 2000 BACKGROUND Pulmonaryarterial hypertension (PAH) in patients with sleep apnoea syndrome(SAS) is classically ascribed to associated chronic obstructivepulmonary disease (COPD). The aim of this retrospective study was toevaluate the possible occurrence of PAH as a complication of SAS inpatients without COPD. METHODS Right heartcatheterisation was performed in 44 patients with SAS and without COPDconfirmed by polysomnography (apnoea index >5/h) admitted for theadministration of nasal continuous positive airway pressure (CPAP). RESULTS PrecapillaryPAH, defined as mean pulmonary arterial pressure of >20 mm Hg withpulmonary capillary wedge pressure <15 mm Hg, was observed in 12/44(27%) patients with SAS. There were no significant differences inapnoea index between patients with (PAH+) and those without PAH (PAH-)(42.6 (26.3) versus 35.8 (21.7) apnoeas/h). The PAH+ group differedsignificantly from the PAH- group in the following respects: lowerdaytime arterial oxygen tension (Pa O 2 ) (9.6 (1.1) versus 11.3 (1.5) kPa, p=0.0006); higher daytime arterial carbondioxide tension (Pa CO 2 ) (5.8 (0.5) versus 5.3 (0.5) kPa, p=0.002); more severe nocturnal hypoxaemia with a higherpercentage of total sleep time spent at Sa O 2 <80% (32.2 (28.5)% versus 10.7 (18.8)%, p=0.005); and higher bodymass index (BMI) (37.4 (6) versus 30.3 (6.7) kg/m 2 ,p=0.002). The PAH+ patients had significantly lower values of vitalcapacity (VC) (87 (14)% predicted versus 105 (20)% predicted, p=0.005), forced expiratory volume in one second (FEV 1 ) (82 (14)% predicted versus 101 (17)% predicted, p=0.001), expiratoryreserve volume (40 (16)% predicted versus 77 (41)% predicted,p=0.003), and total lung capacity (87 (13)% predicted versus 98 (18)%predicted, p=0.04). Stepwise multiple regression analysis showed thatmean pulmonary artery pressure (PAPm) was positively correlated with BMI and negatively with Pa O 2 . CONCLUSION Pulmonaryarterial hypertension is frequently observed in patients with SAS, evenwhen COPD is absent, and appears to be related to the severity ofobesity and its respiratory mechanical consequences. Keywords: sleep apnoea syndrome; pulmonary arterialhypertension; obesity © 2000 by Thorax This article has been cited by other articles: ( Search Google Scholar for Other Citing Articles ) R. J. Barst, M. McGoon, A. Torbicki, O. Sitbon, M. J. Krowka, H. Olschewski, and S. Gaine Diagnosis and differential assessment of pulmonary arterial hypertension J. Am. Coll. Cardiol., June 16, 2004;43(12_Suppl_S):40S - 47S. [Abstract] [Full Text] [PDF] J. Zielinski Effects of intermittent hypoxia on pulmonary haemodynamics: animal models versus studies in humans Eur. Respir. J., January 1, 2005;25(1):173 - 180. [Abstract] [Full Text] [PDF] E. Weitzenblum and A. Chaouat Hypoxic pulmonary hypertension in man: what minimum daily duration of hypoxaemia is required? Eur. Respir. J., August 1, 2001;18(2):251 - 253. [Full Text] [PDF] C. W. Atwood Jr, D. McCrory, J. G. N. Garcia, S. H. Abman, and G. S. Ahearn Pulmonary Artery Hypertension and Sleep-Disordered Breathing: ACCP Evidence-Based Clinical Practice Guidelines Chest, July 1, 2004;126(1_suppl):72S - 77S. [Abstract] [Full Text] [PDF] D. S. Hui, F. W. Ko, J. P. Fok, M. C. Chan, T. S. Li, B. Tomlinson, and G. Cheng The Effects of Nasal Continuous Positive Airway Pressure on Platelet Activation in Obstructive Sleep Apnea Syndrome Chest, May 1, 2004;125(5):1768 - 1775. [Abstract] [Full Text] J. o-D. L. Lattimore, D. S. Celermajer, and I. Wilcox Obstructive sleep apnea and cardiovascular disease J. Am. Coll. Cardiol., May 7, 2003;41(9):1429 - 1437. [Abstract] [Full Text] [PDF] S. Boyer and V. Kapur Obstructive Sleep Apnea: Its Relevance in the Care of Diabetic Patients Clin. Diabetes, July 1, 2002;20(3):126 - 132. [Abstract] [Full Text] [PDF] J. W. H. Fung, T. S. T. Li, D. K. L. Choy, G. W. K. Yip, F. W. S. Ko, J. E. Sanderson, and D. S. C. Hui Severe Obstructive Sleep Apnea Is Associated With Left Ventricular Diastolic Dysfunction Chest, February 1, 2002;121(2):422 - 429. [Abstract] [Full Text] [PDF] HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS Great Skin - Peter Home Lamas Beauty Kits Night Radiance Hair Care Skin Care Bath & Body Care Beauty & Health Books Product Testimonials Press Coverage About Us Gift Certificates Guarantee Product Feedback Request Catalog Product Usage Monthly Special Beauty BLOG Wholesalers Lamas Beauty TV Click here for TV Specials seen on Healthy Living Lamas Beauty Club EXCLUSIVE! Special product offers from Lamas Beauty! Enter email address and press Submit. 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Here's a few you can dismiss for all time. Drinking eight glasses of water will hydrate your skin. Don't get us wrong - drinking water is a great health tip and good for your whole body - inside. However, your skin becomes dry from external aggressors - cold, sun, wind, pollution, even room heaters and air conditioners, so it needs something that works from the outside in, i.e., moisturizer. The Real Deal. Right after you wash your face or shower, massage in your moisturizer while skin is still damp to get the benefits of the water and the moisturizer. Smoking and caffeine cause dry skin. Tests show that caffeine has no direct effect on your skin, but it does deplete water from the body. Smoking only works indirectly to make your skin old before its time, by decreasing circulation so the skin doesn't get as much oxygen - which is essential in creating and maintaining healthy skin cells. In addition, the repetitive eye squinting and pursing of the lips while you smoke can cause premature wrinkling around the eyes and the mouth. Baby oil or petroleum jelly heals dry, chapped skin better than moisturizer. Baby Oil and Petroleum Jelly are good barriers to help prevent further moisture loss - but they don't put anything back in the bank. Moisturize dry, chapped areas - then, if you want, seal the added hydration in, with a thin layer of baby oil or petroleum jelly. You can scrub acne away. Coarse, heavy-grained exfoliators are often recommended for acne-prone, oily skin. But used too often and too vigorously they can actually aggravate acne by opening the cysts and by encouraging the skin to produce even more oil to compensate for what's being ruthlessly stripped away. Instead, use a medium strength exfoliator, suspended in a gel or paste, and don't overdo it. Beauty Solutions HomePage ! Professional Beauty Tips Series ! | You And The Sun Series ! 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