Lotion Table of Contents















Betnovate Lotion , SPC from the eMC Go to the electronic Medicines Compendium ( e MC) Homepage GlaxoSmithKline UK Stockley Park West Uxbridge Middlesex UB11 1BT Telephone: +44 (0)800 221 441 Facsimile: +44 (0)208 990 4321 Medical Information e-mail: customercontactuk@gsk.com Document last updated on the e MC: Fri 18 February 2005 Betnovate Lotion Table of Contents 1. NAME OF THE MEDICINAL PRODUCT 2. QUALITATIVE AND QUANTITATIVE COMPOSITION 3. PHARMACEUTICAL FORM 4. CLINICAL PARTICULARS 4.1 Therapeutic indications 4.2 Posology and method of administration 4.3 Contraindications 4.4 Special warnings and precautions for use 4.5 Interaction with other medicinal products and other forms of interaction 4.6 Pregnancy and lactation 4.7 Effects on ability to drive and use machines 4.8 Undesirable effects 4.9 Overdose 5. PHARMACOLOGICAL PROPERTIES 5.1 Pharmacodynamic properties 5.2 Pharmacokinetic properties 5.3 Preclinical safety data 6. PHARMACEUTICAL PARTICULARS 6.1 List of excipients 6.2 Incompatibilities 6.3 Shelf life 6.4 Special precautions for storage 6.5 Nature and contents of container 6.6 Special precautions for disposal Administrative Data 7. MARKETING AUTHORISATION HOLDER 8. MARKETING AUTHORISATION NUMBER(S) 9. DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 10. DATE OF REVISION OF THE TEXT 1. NAME OF THE MEDICINAL PRODUCT Betnovate Lotion 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Betamethasone Valerate 0.122% w / w 3. PHARMACEUTICAL FORM Lotion 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Betamethasone valerate is an active topical corticosteroid, which produces a rapid response in those inflammatory dermatoses that are normally responsive to topical corticosteroid therapy, and is often effective in the less responsive conditions such as psoriasis. Betnovate preparations are indicated of the treatment of: eczema in children and adults; including atopic and discoid eczemas, prurigo nodularis; psoriasis (excluding widespread plaque psoriasis); neurodermatoses, including lichen simplex, lichen planus, seborrhoeic dermatitis; contact sensitivity reactions; discoid lupus erythematosus and they may be used as an adjunct to systemic steroid therapy in generalised erythroderma. 4.2 Posology and method of administration A small quantity of Betnovate should be applied to the affected area two or three times daily until improvement occurs. It may then be possible to maintain improvement by applying once a day, or even less often. If no improvement is seen within two to four weeks, reassessment of the diagnosis or referral, may be necessary. Betnovate lotion is particularly suitable when a minimal application to a large area is required. In the more resistant lesions, such as the thickened plaques of psoriasis on elbows and knees, the effect of Betnovate can be enhanced, if necessary, by occluding the treatment area with polythene film. Overnight occlusion only is usually adequate to bring about a satisfactory response in such lesions. Thereafter improvement can usually be maintained by regular application without occlusion. Children Courses should be limited to five days if possible. Occlusion should not be used. 4.3 Contraindications Rosacea, acne vulgaris and perioral dermatitis. Primary cutaneous viral infections (e.g. herpes simplex, chickenpox). Hypersensitivity to the preparation. The use of Betnovate skin preparations is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi (e.g. candidiasis, tinea); or bacteria (e.g. impetigo); primary or secondary infections due to yeast; perianal and genital pruritus; dermatoses in children under 1 year of age, including dermatitis and napkin eruptions. 4.4 Special warnings and precautions for use Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression, with or without clinical features of Cushing's syndrome, can occur even without occlusion. In this situation, topical steroids should be discontinued gradually under medical supervision because of the risk of adrenal insufficiency (see section 4.8 Undesirable Effects and Secion 4.9 Overdose). The face, more than other areas of the body, may exhibit atrophic changes after prolonged treatment with potent topical corticosteroids. This must be borne in mind when treating such conditions as psoriasis, discoid lupus erythematosus and severe eczema. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye, as glaucoma might result. If used in childhood, or on the face, courses should be limited to five days and occlusion should not be used. Topical corticosteroids may be hazardous in psoriasis for a number of reasons including rebound relapses, development of tolerance, risk of generalised pustular psoriasis and development of local or systemic toxicity due to impaired barrier function of the skin. If used in psoriasis careful patient supervision is important. Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions, which have become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents. Bacterial infection is encouraged by the warm moist conditions induced by occlusive dressings and so the skin should be cleansed before a fresh dressing is applied. Further information: The least potent corticosteroid, which will control the disease, should be selected. None of these preparations contain lanolin. Betnovate cream and ointment and the corresponding RD preparations do not contain parabens. Betnovate lotion contains parabens. 4.5 Interaction with other medicinal products and other forms of interaction None known 4.6 Pregnancy and lactation There is inadequate evidence of safety in human pregnancy. Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development including cleft palate and intrauterine growth retardation. There may therefore be a very small risk of such effects in the human foetus. 4.7 Effects on ability to drive and use machines None known. 4.8 Undesirable effects Adverse events are listed below by system organ class and frequency. Frequencies are defined as: very common ( 1/10), common ( 1/100 and <1/10), uncommon ( 1/1000 and <1/100), rare ( 1/10,000 and <1/1000) and very rare (<1/10,000) including isolated reports. Very common, common and uncommon events were generally determined from clinical trial data. The background rates in placebo and comparator groups were not taken into account when assigning frequency categories to adverse events derived from clinical trial data, since these rates were generally comparable to those in the active treatment group. Rare and very rare events were generally determined from spontaneous data. Immune system disorders Very rare: Hypersensitivity. If signs of hypersensitivity appear, application should stop immediately. Endocrine disorders Very rare: Features of Cushing's syndrome As with other topical corticosteroids, prolonged use of large amounts or treatment of extensive areas can result in sufficient systemic absorption to produce suppression of the HPA axis and the clinical features of Cushing's syndrome (see Section 4.4 Special Warnings and Precautions for use). These effects are more likely to occur in infants and children, and if occlusive dressings are used. In infants the napkin may act as an occlusive dressing. Skin and subcutaneous tissue disorders Common: Local skin burning and pruritus. Very rare: Local atrophic changes in the skin such as thinning, striae and dilatation of the superficial blood vessels may be caused by prolonged and intensive treatment with highly active corticosteroid preparations, particularly when occlusive dressings are used or when skin folds are involved. Pigmentation changes, hypertrichosis, allergic contact dermatitis, exacerbation of symptoms, pustular psoriasis (due to treatment of psoriasis with corticosteroids or its withdrawal: see Section 4.4. Special Warnings and Precautions for use) 4.9 Overdose Acute overdosage is very unlikely to occur. However, in the case of chronic overdosage or misuse the features of Cushing's syndromemay appear and in this situation topical steroids should be discontinued gradually under medical supervision (see Section 4.4 Special Warnings and Precautions for use). 5. PHARMACOLOGICAL PROPERTIES 5.1 Pharmacodynamic properties Betamethasone valerate is an active corticosteroid with topical anti-inflammatory activity. 5.2 Pharmacokinetic properties The extent of percutaneous absorption of topical corticosteroid is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or other disease processes in the skin increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolised primarily by the liver and are then excreted by the kidneys. 5.3 Preclinical safety data There are no preclinical data of relevance to the prescriber which are additional to that in other sections of the SmPC. 6. PHARMACEUTICAL PARTICULARS 6.1 List of excipients Methyl Hydroxybenzoate BP Xanthan Gum USP Cetostearyl Alcohol BP Liquid Paraffin BP Isopropyl Alcohol BP Glycerol BP Cetomacrogol 1000 BP Sodium citrate BP Citric Acid Monohydrate BP Purified Water BP 6.2 Incompatibilities None known. 6.3 Shelf life 36 months 6.4 Special precautions for storage Store below 25°C 6.5 Nature and contents of container Polyethylene squeeze bottle with a polyethylene nozzle and a polystyrene or polyethylene cap or White High Density Polyethylene (HDPE) Hostalen GF4750 and Remafin white CEG 020 containerwith a polyethylene nozzle and a polystyrene or polyethylene cap. Pack size: 20 ml; 100 ml Not all pack sizes may be marketed 6.6 Special precautions for disposal No special instructions Administrative Data 7. MARKETING AUTHORISATION HOLDER Glaxo Wellcome UK Limited T/A GlaxoSmithKline UK Stockley Park West Uxbridge Middlesex UB11 1BT 8. MARKETING AUTHORISATION NUMBER(S) PL 10949/0044 9. DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION 10 September 1997 10. DATE OF REVISION OF THE TEXT 25th January 2005



Lip Balms & Moisturizers

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Lotion Body Bronzing Lotion

Body Bronzing Lotion | Teach Soap | Lotion Recipes Soap Making Instructions | How to Make Soap |Fun Soap Making Projects from Teach Soap! Return to Home Page Using Emulsifying Wax Rendering Tallow New! Keeping Organized Soap Making Methods Pricing Melt and Pour Soaps Pricing Cold Process Soaps Finding a Craft Show Men's Fragrances History of Fragrance Oils Reusing your Packaging Business Insurance Soap Coloring Options Building a Soap Cutter Basic Melt and Pour Fun Soap Recipes Delectable Lip Butters Bath Poof Soaps Night Foot and Hand Créme Elbow and Knee Lotion Body Bronzing Lotion The Soap Gallery 3-D Rock Soap Swirled Scallop Soap Color Blend Embedding Molds Layered Soap Pressed Flower Soap Double Color Pour Basic Rebatch Recipe Amethyst Gem Soap Basic Hot Process Oven Hot Process Soap Looped Swirl Soap Small Batch CP Recipes Gentle Acne Soap Break the Rules Soap Memememe Luxury Bar Shaving Soap Silk Soap Vanilla Caramel Soap Ribbons Soap Bath Bombs Moisturizing Bath Fizzy Tub Tints Fizzy Milk Bombs Water Softening Fizzy Moisture Rich Fizzy Cookie Cutter Soaps Ask Anne-Marie! . Body Bronzing Lotion Recipe by Anne-Marie Faiola Ingredients: 4.5 oz. Jojoba 1.0 oz. Evening Primrose Oil 0.3 oz. Emulsifying wax 0.2 oz. Beeswax 8.0 oz. Distilled water 0.14 oz. Phenonip preservative or GermabenII Micas: Cappuccino, Gold, Light Gold and Copper mica Makes 14 oz. of bronzing lotion. Instructions: 1. Add the Emulsifying Wax, Beeswax, Jojoba and Evening Primrose Oil to either a double boiler or microwave safe cup. 2. Melt all the waxes and oils together. Attempt not to boil the product. 3. Add the Distilled Water to the heated oils and waxes. Stir all ingredients well and combine the two bowls/mixing glasses. 4. Stir all ingredients well and combine the two bowls/mixing glasses. 5. Add the Phenonip. 6. Use a stick blender to emulsify and mix the oils and waxes. Note: This product will not set up until it is fully cooled. Do not pour into containers (containers with a pump are recommended) until you are certain that the lotion is fully blended and will not separate. 7. Once you are certain the product is fully blended and will not separate, add the micas. Always add less than you think you will want to use - you can always add more but can't take the color out. I used 1 full tablespoon of Light Gold Mica, 1/2 tablespoon Cappuccino Mica and 1 teaspoon of Copper Mica. 8. Hand blend this mixture with a spoon or small whisk. You can use the stick blender if the mixture hasn't set up too much. The ratio of micas that you use will depend on your skin tone. My best friend who made the recipe with me used three times as much Cappuccino mica and almost no copper in her recipe since she is much darker than I am in skin tone. Remember, this is a make up product (in addition to acting as a lotion) and will get on your clothes like any other bronzer will. It washes out fairly well. If you have very dark skin, get some Black Oxide as well and add it sparingly to the Cappuccino mica to darken the mixture up. Send us your questions or comments on this and other articles: click here.



Retinal Cream

Neostrata Glycolic Acid, Alpha Hydroxy Acid AHA, Vitamin C, Retinol, Neostrata Hydroquinone Allergy Relief Aromatherapy Back Care Bath Birth Control Books CDs Children's Products Cosmetic Accessories Cough & Cold Relief Dental Care Deodorants Digestive Ear Care Eye Care Feminine Hygiene First Aid Food Foot Care Gift Items Hair Care Herbs Home Health Homeopathy Incontinence Supplies Lip Care Minerals Pain Relievers Pregnancy Accessories Relaxation Products Seasonal Shaving & Hair Removers Skin Care Sleepaids Smoking Cessation Soap Supplements Vitamins CD's available for sale here! View our monthly Newsletter! Sign up for our FREE Newsletter! Can't find what you are looking for? Please let us know how we can help! E-Mail: mail@feelbest.com Phone: 1-888-689-9890 / Fax: 1-877-504-5995 The NeoStrata Difference... These dermatologist-tested products contain clinically proven ingredients such as alpha-hydroxy acids (AHAs), vitamins A (retinal), C, E and K, and botanical extracts. 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Normal to Combination Skin Medium texture, consistent in colour, oily T-zone Multi-Activ Cleansing Milk Multi-activ cleansing milk is a 4-in-1 cleanser that removes face and eye makeup, tones and hydrates in one simple step. 150mL. $23.49 One Step Foaming Gel Cleanser One-Step Foaming Gel Cleanser with glycolic acid gently removes impurities from the surface of the skin. 150mL. $23.99 Daytime Smooting Lotion SPF15 50mL AHA Smoothing and Moisturizing Lotion with SPF 15 is a gentle exfoliant and sunscreen that protects against UVA and UVB rays. 50mL. $23.49 Moisture Lotion SPF15 AHA Smoothing and Moisturizing Lotion with SPF 15. 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