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DJO | Digital Journal of Ophthalmology 40 year old woman with a five-day history of visual loss in the right eye Anthony J. Aldave, M.D. Wills Eye Hospital, Philadelphia, PA History A 40-year-old white female presented to the Wills Eye Hospital Emergency Room with a five day history of blurred vision in the temporal visual field of her right eye. The patient denied any photopsia or other associated visual complaints. PMHx: Ophthalmic Migraines Meds: none SHx: Non contributory FHx: Non contributory Examination Vision:20/20 OU uncorrected Color Plates:Normal color vision OU Pupils: Equal, reactive, No APD Amsler grid: no metamorphopsia OU Visual Field: Confrontational visual fields demonstrated a large temporal scotoma in the right eye; the left eye was full to confrontation. Motility: Full OU Applanation pressure: 19 mmHg OD, 13 mm Hg OS Slit lamp examination:normal anterior segments OU Fundus examination: See Figures 1-3 Figure 1 Figures 1-2. Ophthalmoscopy of the right eye revealed small, discrete white lesions at the level of the deep retina or retinal pigment epithelium scattered over the posterior pole. More lesions are noted nasally. The optic disc and macula were normal. Figure 2 Figure 3 The left fundus was unremarkable Ancillary Testing Angiogram Figure 4 Shows early hypofluorescence of the lesions. Figure 5 Shows late diffuse staining of the RPE and mild staining of the disc Differential Diagnosis Multiple evanescent white dot syndrome (MEWDS) Features: Typically occurs in younger women, with frequent recovery of visual function and resolution of RPE lesions. Noted on ophthalmoscopy: Lesions normally unilateral, multiple white dots are seen at the level of the deep retina or retinal pigment epithelium. The white dots are most prominent in the paramacular area, usually sparing the fovea. Noted on fluorescein angiography: MEWDS lesions usually demonstrate early punctate hyperfluorescence and late staining corresponding to the location of the white dots and mild disc staining. Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) Features: Transient visual loss in younger patients, with frequent recovery of visual function and resolution of RPE lesions. Usually bilateral involvement. Noted on ophthalmoscopy: Usually bilateral, with considerably larger lesions than those associated with MEWDS which leave more obvious RPE alterations after fading Noted on fluorescein angiography: APMPPE lesions block fluorescence early in the angiogram with late staining. Acute retinal pigment epitheliitis Features: Acute visual loss in younger patients, with near total visual recovery in 7-10 weeks. Noted on ophthalmoscopy: Lesions appear as dark dots with surrounding halo of depigmentation; these spots become more pigmented with clinical recovery. Noted on fluorescein angiography: Appear as hypofluorescent areas surrounded by hyperfluorescence. Birdshot retinochoroidopathy Features: Appears in older patients and is bilateral. Does not present with acute loss of vision. Noted on ophthalmoscopy: Manifests as multiple cream-colored lesions at the level of the RPE or deeper. Frequently associated with cystoid macular edema, vitreous reaction, and retinal vascular leakage. Noted on fluorescein angiography: Characteristically, reveals hypofluorescence in the early phase with slight diffuse hyperfluorescence in the late phase. Diagnosis Multiple Evanescent White Dot Syndrome (MEWDS) The patient was felt to have multiple evanescent white dot syndrome and was followed conservatively without treatment. The patient has since experienced a gradual improvement in her visual symptoms with a concomitant resolution of the white lesions. MEWDS, first described in 1984, most commonly affects healthy younger women, as is true in this patient's case. Typically, patients present with rapidly progressive unilateral visual loss. Had formal visual field testing been performed, it is likely that an enlarged blind spot would have been demonstrated. Other characteristic clinical findings in MEWDS, which were not noted in this patient, include a granular appearance of the macula, optic disc edema, retinal vascular sheathing, and vitreal cells. Although the cause of MEWDS remains unknown, ophthalmoscopic localization of the lesions to the deep retina and abnormal electroretinographic studies have pointed to a disorder of the retinal pigment epithelium which secondarily affects the adjacent photoreceptors. Fluorescein angiography is often a valuable tool in confirming a diagnosis of MEWDS in a patient with characteristic fundus findings. Interestingly, this patient did not display the typical early hyperfluorescent spots of MEWDS, but instead had hypofluorescent lesions, which are more characteristic of APMPEE. Although the fundoscopic appearance of the lesions was strongly suggestive of MEWDS, a recovery angiogram would be helpful in confirming the diagnosis; one would expect significantly less RPE alteration than is seen after resolution of APMPEE. Investigators have also suggested that indocyanine green angiography (ICG) may be a useful adjunct in the diagnosis of MEWDS, as it demonstrates a greater number of lesions than are seen with ophthalmoscopy or fluoroscein angiography. MEWDS is usually a self-limited disorder, with resolution of symptoms and the white dots over a 4 to 6 week period. However, a chronic recurrent form of the disease has been described in which multiple recurrences have involved both eyes Additionally, multifocal choroiditis and choroidal neovascularization have been associated with MEWDS, as has persistent enlargement of the blind spot. Patients with acute idiopathic blind spot enlargement (AIBSE) without optic disc edema are likely a subgroup of patients with MEWDS who have rapid resolution of their fundoscopic abnormalities with a protracted enlargement of the blind spot. When these patients are examined after resolution of the white dot lesions and the characteristic fluorescein angiographic findings, the presentation is indistinguishable FROM AIBSE, suggesting that AIBSE may represent a variation of MEWDS. References 1) Jampol LM, Sieving PA., Pugh D, et al: Multiple evanescent white dot syndrome: I.. Clinical findings. Arch Ophthalmol 1984;102:671-674. 2) Gass JDM: Acute posterior multifocal placoid pigment epitheliopathy. Arch Ophthalmol 1968;80:177-185. 3) Krill AE, Deutman AF: Acute retinal pigment epitheliitis. AM J Ophthalmol 1972;74:193-205. 4) Ryan SJ, Maumenee AE: Birdshot retinochoroidopathy. Am J Ophthalmol 1980;89:31-45. 5) Le D, Glaser BM, Murphy RP, Gordon LW, et al:Indocyanine green angiography in multiple evanescent white-dot syndrome. Am J Ophthalmol 1994;117:7-12. 6) Sieving PA, Fishman GA, Jampol LM, et al: Multiple Evanescent white dot syndrome: II. Electrophysiology of the photoreceptots during retinal pigment epithelial disease. Arch Ophthalmol, 1984; 102:675-679. 7) Tsai L, Jampol LM, Pollock SC, et al:Chronic recurrent multiple evanescent white dot syndrome. Retina 1994;14:160-163. 8) Callanan D, Gass DM: Multifocal choroiditis and choroidal neovascularization associated with the multiple evanescent white dot and acute idiopathic blind spot enlargement syndrome. Ophthalmol 1992;99:1678-1685. 9) Hamed LH, Glaser JS, Gass DM, et al: Protracted enlargement of the blind spot in multiple evanescent white dot syndrome. Arch Ophthalmol 1989;107:194-198. 10) Jampol LM: MEWDS, MFC, PIC, AMN, AIBSE, and AZOOR: one disease or many? [editorial]. Retina 1995;15:373-378.



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A Diet for Gorgeous Skin iVillage Beauty & Style Health & Well-being Diet & Fitness Love & Sex Pregnancy & Parenting Home & Food Entertainment Magazines you are here iVillage Cosmopolitan Beauty & Style Beauty Features Cosmopolitan iVillage the Web Subscribe • In This Issue • Past Issue Archive • Free Newsletter • Get Cosmo Headlines Daily • Gift Subscriptions • Customer Service • Write to Us • Cosmo FAQs Experts • Carnal Counselor • Ask Him Anything Sex & Love • Sex Articles • Bedroom Blog • Sex Position of the Week • Sex Tips from Guys • Bedside Astrologer • Daily Horoscopes • Sexual Health • Passion Polls • Sexy Postcards • Kama Sutra Match & Moan Game Beauty & Style • Cosmo's Winter Look • Beauty Q&A • Beauty Features • Cosmo Fashion • Style Secrets Connect with Cosmo • Cosmo Wants to Know • Free Stuff from Cosmo • Cosmo Quiz • Cosmo Exclusives • For Guys Only • Message Boards • Red-Hot Reads • Confess to Cosmo • Make Cosmo Your Homepage Men • Guy Candy Gallery • Man Match Game • The Man Menu • His Moan Zones • Sex Up Your Screen iVILLAGE TOPICS • Cheating • Hair • Bedroom Concerns • Safe Sex • Taboos • What Guys Want • Makeovers A Diet for Gorgeous Skin BY LESLIE PEPPER (PHOTO: BETH STUDENBERG) New research proves that following a few food rules can give you a clear, lit-from-within complexion. We have the menu tweaks to make, starting today. The best get-flawless-skin regimen? It's not a trendy spa treatment. It's a way of eating. Yeah, yeah, we know that for years, experts said greasy foods and chocolate don't cause pimples and that, overall, what you eat has no effect on your skin. But new research proves otherwise. So follow these four rules on how to feed your face. Lay Off the White Stuff Turns out french fries do cause breakouts. But it's not the grease that's the culprit, it's the potatoes. In a recent study, researchers looked at 1,200 natives of an island near Papua New Guinea and 115 hunter-gatherers in Paraguay and couldn't find a single zit in the lot. What's their secret? "A diet that consists almost exclusively of protein, fruits and veggies," says Loren Cordain, Ph.D., professor of health and exercise science at Colorado State University and lead author of the study. Absent from their meals: the simple carbohydrates -- such as white bread, pasta, rice, potatoes and sweets -- that are the basis of our modern diet. These carbs send our insulin levels soaring, and researchers speculate that this sets off a series of reactions that leads to breakouts. Simple food switch: Instead of refined white carbs, go for moderate amounts of complex ones like whole-grain bread, brown rice and whole-wheat pasta (they're digested more slowly and don't lead to that skin-sabotaging insulin spike). PAGE 1 OF 4 NEXT: Savor Seafood in this article PAGE 1: Lay Off the White Stuff PAGE 2: Savor Seafood PAGE 3: Banish Blush Triggers PAGE 4: Indulge in Olive Oil printer friendly version Subscribe to Cosmopolitan related links SUBSCRIBE: Get more of what you want from Cosmo! Click for details ARTICLE: Banish Summer Bummers ARTICLE: New Season, Sexy New Hairstyles ARTICLE: The Cosmo Beauty Awards ARTICLE: The Best Summer Beauty Buys ARTICLE: Acne à la Carte USA: 12 issues for $18 • Non-USA: click here Name Address 1 Address 2 City State Zip Email Yes, I Would like to receive special offers and discounts by email from Cosmopolitan ( privacy policy ) Send this page to a friend Friend's Email: Home | Subscribe | Experts | Sex & Love | Beauty & Style Connect with Cosmo | Men Name Address City State Postal Code Email We'll bill you later -- 12 issues for just $18. Non-USA Gift Subscriptions Subscriptions Service Write to us Get Cosmo Headlines Daily! On iVillage: Home Topics A-Z Message Boards Quizzes Newsletters Free Stuff Astrology Multimedia Blogs Beauty & Style Health & Well-Being Diet & Fitness Love & Sex Pregnancy & Parenting Home & Food Entertainment Special Sections: Personals Meet Marcia Cross Snack Swapper Car Safety Shopping Coupons Games Magazines: Cosmopolitan Country Living Good Housekeeping House Beautiful Marie Claire Redbook Town & Country Terms of Service Privacy Policy About iVillage Customer Support ©1995-2006 iVillage. All Rights Reserved.



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Facial Plastic Surgery Family

Archives of Facial Plastic Surgery Select Journal or Resource JAMA & Archives Home JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Otolaryngology—Head & Neck Surgery Pediatrics & Adolescent Medicine Surgery Student JAMA (1998-2004) JAMA & Archives CME Calendar of Events JAMA CareerNet For The Media Users’ Guides to the Medical Literature Peer Review Congress Vol. 8No. 1, Jan-Feb 2006 Access Archives • Sign in/out • Subscribe • Register as a Guest • Manage My Account • E-mail Alerts • RSS Feeds • About Archives Information for • Authors/Reviewers • Readers • Institutions/Libraries • Subscription Agents • News Media • Advertisers Related Sites • Calendar of Events • Users’ Guides to the Medical Literature Highlights From This Issue Archives of Facial Plastic Surgery Readers: Please complete our brief survey -- Beauty William Cumming, Family Stroll , 2002, American. MORE Mandibular Lengthening in Micrognathic Infants With the Internal Distraction Device Roy and Patel report their experience treating 8 infants with isolated Pierre Robin sequence who underwent mandibular lengthening with internal microdistractors. MORE Internal Brow Elevation at Blepharoplasty Burroughs and colleagues reviewed 1000 patients who underwent internal brow elevation without periosteal fixation. All patients experienced some degree of temporary forehead hypesthesia, but long-term sensory complaints were reported in only 2 patients. MORE Archives of Facial Plastic Surgery Readers: Please complete our brief survey The M-Arch Model Adamson and colleagues proposed the M-Arch Model, which expands the nasal tripod concept by considering the nasal tip tripod in its entirety as an arch and stresses the importance of the overall length of the medial, intermediate, and lateral crural segments as they formed a cartilaginous arch. FREE ARTICLE MORE Quantitative Assessment of Nasal Changes After Maxillomandibular Surgery Using a 3-Dimensional Digital Imaging System Honrado and colleagues used of 3-dimensional digital imaging techniques to measure nasal changes after maxillary advancement surgery, with and without rotation, demonstrating the use of 3-D imaging in the planning, execution, and postoperative assessment of patients undergoing orthognathic surgery. MORE NEW: Add Archives of Facial Plastic Surgery RSS feed Title Text on right. MORE IMAGE ON LEFT *END*-- Title Text below. MORE IMAGE ON TOP *END* -- Title Text only. MORE NO IMAGE *END -- Theme Issue: VASCULAR BIRTHMARKS -- HOME | CURRENT ISSUE | PAST ISSUES | COLLECTIONS | CAREERNET | CONTACT US | HELP CONDITIONS OF USE | PRIVACY POLICY © 2006 American Medical Association. All Rights Reserved.



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